Etiology of IBR

IBR is caused by bovine herpesvirus 1 (BoHV-1).

Family: Herpesviridae
Subfamily: Alphaherpesviridae

There are two subtypes of Bovine Herpesvirus 1:

• BoHV-1.1
• BoHV-1.2

Structural proteins

BoHV-1 is a DNA virus with several structural proteins among which at least 11 transmembrane glycoproteins. Glycoproteins play important roles such as virus-cell interactions and interactions with the immune system. Glycoproteins gB, gD, gH, gK, gL are essential for virus replication, while gC, gG, gI, gE, gM and gN are not essential.